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Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

Abstract:

Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on multiple immunoreceptor tyrosine-based activation motifs (ITAMs). Intriguingly, Lck sequentially phosphorylates ITAMs and ZAP-70, a cytosolic kinase, binds to phosphorylated ITAMs with differential af...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1003004

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
9
Issue:
3
Pages:
ARTN e1003004
Publication date:
2013-03-28
Acceptance date:
2013-02-05
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Source identifiers:
387503
Language:
English
Keywords:
UUID:
uuid:35cfae67-6fa1-4c47-b7f1-903cacab8b2e
Local pid:
pubs:387503
Deposit date:
2013-11-16

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