The Drosophila GAGA transcription factor is associated with specific regions of heterochromatin throughout the cell cycle.

Journal article

In virtually all eukaryotes the centromeric regions of chromosomes are composed of heterochromatin, a specialized form of chromatin that is rich in repetitive DNA sequences and is transcriptionally relatively silent. The Drosophila GAGA transcription factor binds to GA/CT-rich sequences in many Drosophila promoters, where it activates transcription, apparently by locally altering chromatin structure and allowing other transcription factors access to the DNA. Here we report the paradoxical fin...

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Authors: Raff, J; Kellum, R; Alberts, B

• Journal: EMBO journal
• Volume: 13
• Issue: 24
• Pages: 5977-5983
• Publication date: 1994-12-01
• EISSN: 1460-2075
• ISSN: 0261-4189
• Language: English
• Keywords: Animals; DNA-Binding Proteins; Homeodomain Proteins; Sequence Analysis, DNA; Cell Cycle; Drosophila Proteins; Cells, Cultured; Heterochromatin; Drosophila melanogaster; Fluorescent Antibody Technique; Chromosomes; Repetitive Sequences, Nucleic Acid; Transcription Factors; Centromere; DNA, Complementary; Cloning, Molecular