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Journal article

Highly enantioselective rhodium-catalyzed cross-coupling of boronic acids and racemic allyl halides

Abstract:

Although Csp2-Csp2 Suzuki-Miyaura couplings (SMCs) are widely used in small-molecule synthesis, related methods that allow the incorporation of Csp3-hybridized coupling partners, particularly in an asymmetric manner, are less developed. This protocol describes catalytic asymmetric SMC reactions that provide access to enantiomerically enriched cyclic allylic products. The method couples racemic allyl halide starting materials with sp2-hybridized boronic acid derivatives and is compatible with ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41596-019-0209-8

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-8688-5609
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0001-7629-0997
Publisher:
Springer Nature Publisher's website
Journal:
Nature Protocols Journal website
Volume:
14
Pages:
2972–2985
Publication date:
2019-09-20
Acceptance date:
2019-06-06
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Pmid:
31541227
Source identifiers:
1056038
Language:
English
Keywords:
Pubs id:
pubs:1056038
UUID:
uuid:35c95a4c-bb76-4b90-b37e-1f87bebdba83
Local pid:
pubs:1056038
Deposit date:
2019-09-30

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