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MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.

Abstract:

MeCP2 is a transcription factor that recognizes and binds symmetrically methylated CpG dinucleotides to repress transcription. MeCP2 can associate with the Sin3a/histone deacetylase corepressor complex and mediate repression in a histone deacetylase-dependent manner. In extracts from rodent tissues, cultured cells, and Xenopus laevis oocytes, we find that only a small amount of mammalian MeCP2 interacts with Sin3a and that this interaction is not stable. Purification of rat brain MeCP2 (53 kD...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m408284200

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Journal of biological chemistry
Volume:
279
Issue:
45
Pages:
46490-46496
Publication date:
2004-11-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
99842

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