A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

Journal article

Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1). Both locus and allelic heterogeneity have been reported in this genomic region. To clarify whether HLA-DRB1 itself, nearby genes in the region encoding the MHC or combinations of these loci underlie susceptibility to multiple sclerosis, we genotyped 1,185 Canadian and Finnish families with multiple sclerosis (n = 4,203 individuals) w...

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Authors: Lincoln, MR; Montpetit, A; Cader, M; Saarela, J; Dyment, D

• Publication status: Published
• Journal: Nature genetics
• Volume: 37
• Issue: 10
• Pages: 1108-1112
• Publication date: 2005-10-01
• DOI: 10.1038/ng1647
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: HLA-DR Antigens; Humans; Genetic Predisposition to Disease; Finland; European Continental Ancestry Group; Multiple Sclerosis; Polymorphism, Single Nucleotide; Histocompatibility Antigens Class II; HLA-DRB1 Chains; Major Histocompatibility Complex; Canada