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Journal article

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.

Abstract:

The human major histocompatibility complex (MHC) class II region is associated with genetic susceptibility to multiple sclerosis (MS). Roles for HLA class I loci have been supported in several case-control studies, but this methodology does not consider the known linkage disequilibrium (LD) between class I and II loci. In 1258 individuals from 294 MS families, we analysed class I and II interactions. Using transmission disequilibrium test and haplotype analyses, we found positive associations...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddm142

Authors


Barnardo, MC More by this author
Lincoln, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Journal:
Human molecular genetics
Volume:
16
Issue:
16
Pages:
1951-1958
Publication date:
2007-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:35bbd89d-4927-4a71-9fe9-a8f81e01f85d
Source identifiers:
33897
Local pid:
pubs:33897

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