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T cell suppression in vitro. I. Role in regulation of antibody responses.

Abstract:

Suppression of the antibody response by supraoptimal numbers of T helper cells was studied in vitro and found to have both a specific and a nonspecific component. Suppression did not depend on direct cell contact of T and B cells, as supernatants of activated T cells were just as inhibitory. Suppression by excess T cells (or T cell supernatant) was abrogated by the addition of macrophages. By using a tolerance induction protocol, it was shown that T cell supernatants induce partial tolerance ...

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Publisher copy:
10.1002/eji.1830041005

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
4
Issue:
10
Pages:
660-666
Publication date:
1974-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:35b206c4-967f-4f08-88f1-23d3cc77c507
Source identifiers:
481689
Local pid:
pubs:481689

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