Suppression of the antibody response by supraoptimal numbers of T helper cells was studied in vitro and found to have both a specific and a nonspecific component. Suppression did not depend on direct cell contact of T and B cells, as supernatants of activated T cells were just as inhibitory. Suppression by excess T cells (or T cell supernatant) was abrogated by the addition of macrophages. By using a tolerance induction protocol, it was shown that T cell supernatants induce partial tolerance ...Expand abstract
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T cell suppression in vitro. I. Role in regulation of antibody responses.
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