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Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body.

Abstract:

1. The effects of changing PCO2 extracellular pH (pHo) and HCO3- on intracellular pH (pHi) were studied in isolated neonatal rat type-I carotid body cells using the pH-sensitive fluoroprobe, carboxy-SNARF-1. 2. Simulated respiratory acidosis and alkalosis (i.e. changes in PCO2 at constant HCO3-) led to rapid (half-time t0.5 = 3 s) monotonic changes in pHi. The relationship between pHi and pHo under these conditions was linear, steep (0.63 pHi/pHo) and remarkably similar to the response predic...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Vaughan-Jones, RD More by this author
Lagadic-Gossmann, D More by this author
Journal:
The Journal of physiology
Volume:
444
Issue:
1
Pages:
703-721
Publication date:
1991-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:35a75ece-bc7f-449e-b481-d6255779b9d0
Source identifiers:
113636
Local pid:
pubs:113636

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