Journal article icon

Journal article

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.

Abstract:

An emergent viral pathogen termed ‘severe fever with thrombocytopenia syndrome virus’ (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of endosomal host and viral membranes during cell entry. Here, we describe the trimeric postfusion structure of SFTSV Gc, revealing that the molecular transformations the phleboviral Gc undergoes upon h...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1073/pnas.1603827113

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
Elliott, RM More by this author
Expand authors...
More from this funder
Funding agency for:
Harlos, KPG
More from this funder
Funding agency for:
Huiskonen, JT
International AIDS Vaccine Initiative More from this funder
Expand funders...
Publisher:
National Academy of Sciences. Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
113
Issue:
26
Pages:
7154-7159
Publication date:
2016-06-05
Acceptance date:
2016-05-17
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:35a73c52-f157-4f4c-8457-bb2fd832d81e
Source identifiers:
629328
Local pid:
pubs:629328

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP