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Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.

Abstract:

Strains of Escherichia coli persist within the human gut as normal commensals, but are frequent pathogens and can cause recurrent infection. Here we show that, in contrast to E. coli subjected to opsonic interactions stimulated by the host's immune response, E. coli that bind to the macrophage surface exclusively through the bacterial lectin FimH can survive inside the cell following phagocytosis. This viability is largely due to the attenuation of intracellular free-radical release and of ph...

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Publication status:
Published

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Publisher copy:
10.1038/39376

Authors


Baorto, DM More by this author
Malaviya, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
van der Merwe, A More by this author
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Journal:
Nature
Volume:
389
Issue:
6651
Pages:
636-639
Publication date:
1997-10-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:35812db9-5788-4dc9-ae9d-ee5bfc5431aa
Source identifiers:
482585
Local pid:
pubs:482585

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