Strains of Escherichia coli persist within the human gut as normal commensals, but are frequent pathogens and can cause recurrent infection. Here we show that, in contrast to E. coli subjected to opsonic interactions stimulated by the host's immune response, E. coli that bind to the macrophage surface exclusively through the bacterial lectin FimH can survive inside the cell following phagocytosis. This viability is largely due to the attenuation of intracellular free-radical release and of ph...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic.
If you are the owner of this record, you can report an update to it here: Report update to this record