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The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.

Abstract:

The TGFbeta-related growth factor Nodal governs anteroposterior (AP) and left-right (LR) axis formation in the vertebrate embryo. A conserved intronic enhancer (ASE), containing binding sites for the fork head transcription factor Foxh1, modulates dynamic patterns of Nodal expression during early mouse development. This enhancer is responsible for early activation of Nodal expression in the epiblast and visceral endoderm, and at later stages governs asymmetric expression during LR axis format...

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Publication status:
Published

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Authors


Norris, DP More by this author
Brennan, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Robertson, EJ More by this author
Journal:
Development (Cambridge, England)
Volume:
129
Issue:
14
Pages:
3455-3468
Publication date:
2002-07-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:3579a2b8-0930-4bf0-aeb7-2bf7d7516c98
Source identifiers:
25750
Local pid:
pubs:25750

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