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Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.

Abstract:

Combining artemisinin or a derivative with mefloquine increases cure rates in falciparum malaria patients, reduces transmission, and may slow the development of resistance. The combination of artesunate, given for 3 days, and mefloquine is now the treatment of choice for uncomplicated multidrug-resistant falciparum malaria acquired on the western or eastern borders of Thailand. To optimize mefloquine administration in this combination, a prospective study of mefloquine pharmacokinetics was co...

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Publication status:
Published

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Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Simpson, JA More by this author
Teja-Isavatharm, P More by this author
Luxemburger, C More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
43
Issue:
2
Pages:
341-346
Publication date:
1999-02-05
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:3568e011-741b-4d8b-b51d-fff5b90019cf
Source identifiers:
14722
Local pid:
pubs:14722

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