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Journal article

Mdm2 targets the p53 transcription cofactor JMY for degradation.

Abstract:

We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a mechanistic level, Mdm2 regulation of JMY requires the Mdm2 RING (really interesting new gene) finger, which promotes the ubiquitin-dependent degradation of JMY. However, regulation of JMY occurs i...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7400855

Authors


Journal:
EMBO reports
Volume:
8
Issue:
1
Pages:
84-90
Publication date:
2007-01-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:355b2ad1-9807-483f-beb4-427936a72544
Source identifiers:
257895
Local pid:
pubs:257895

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