- Abstract:
-
We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a mechanistic level, Mdm2 regulation of JMY requires the Mdm2 RING (really interesting new gene) finger, which promotes the ubiquitin-dependent degradation of JMY. However, regulation of JMY occurs i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.embor.7400855
-
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- Journal:
- EMBO reports
- Volume:
- 8
- Issue:
- 1
- Pages:
- 84-90
- Publication date:
- 2007-01-05
- DOI:
- EISSN:
-
1469-3178
- ISSN:
-
1469-221X
- URN:
-
uuid:355b2ad1-9807-483f-beb4-427936a72544
- Source identifiers:
-
257895
- Local pid:
- pubs:257895
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Mdm2 targets the p53 transcription cofactor JMY for degradation.
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