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Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.

Abstract:

BACKGROUND: Minimal residual disease (MRD) is the most sensitive and specific predictor of relapse risk in children with acute lymphoblastic leukaemia (ALL) during remission. We assessed whether treatment intensity could be adjusted for children and young adults according to MRD risk stratification. METHODS: Between Oct 1, 2003 and June 30, 2011, consecutive children and young adults (aged 1-25 years) with ALL from the UK and Ireland were recruited. Eligible patients were categorised into cli...

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Publication status:
Published

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Authors


Goulden, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Mitchell, C More by this author
Hancock, J More by this author
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Journal:
The Lancet. Oncology
Volume:
14
Issue:
3
Pages:
199-209
Publication date:
2013-03-05
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
URN:
uuid:3554d191-3304-4f9d-90db-fb9a5648a1dd
Source identifiers:
394507
Local pid:
pubs:394507

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