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The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries

Abstract:

Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that is transported to the capillary lumen by an endothelial cell protein, GPIHBP1. For LPL-mediated lipolysis to occur, TRLs must bind to the lumen of capillaries. This process is often assumed to involve heparan sulfate proteoglycans (HSPGs), but we suspected that TRL margination might instead require GPIHBP1. Indeed, TRLs marginate along the heart capillaries of wild-type but not Gpihbp1-/- mice,...

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Publisher copy:
10.1016/j.cmet.2014.01.017

Authors


Goulbourne, CN More by this author
Nobumori, C More by this author
Hoenger, A More by this author
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Publisher:
Cell Press
Journal:
Cell Metabolism
Volume:
19
Issue:
5
Pages:
849-860
Publication date:
2014-05-06
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
URN:
uuid:355487e8-da93-43a7-a765-0e67a1e34531
Source identifiers:
465861
Local pid:
pubs:465861
Language:
English

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