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Journal article

Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.

Abstract:

Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorph...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02276-10

Authors


Corrah, TW More by this author
Goonetilleke, N More by this author
Kopycinski, J More by this author
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Journal:
Journal of virology
Volume:
85
Issue:
7
Pages:
3367-3374
Publication date:
2011-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:35538a79-c0d4-4ceb-88ac-14bee10908b5
Source identifiers:
112555
Local pid:
pubs:112555

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