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Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer

Abstract:

Purpose: To examine the in vitro regulation of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in breast cancer cells and the in vivo predictive role for the efficacy of chemoendocrine primary therapy in patients with breast cancer. Materials and Methods: HAI-2 regulation was studied in a panel of breast cancer cell lines comparing normoxia to hypoxia. The effect of HIF-1α RNAi on HAI-2 expression was evaluated in these cells. HAI-2 was examined in breast cancer using in situ hybr...

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Publication status:
Published

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Journal:
CLINICAL CANCER RESEARCH
Volume:
13
Issue:
2
Pages:
550-558
Publication date:
2007-01-15
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Source identifiers:
125207
Language:
English
Pubs id:
pubs:125207
UUID:
uuid:354f7569-9fec-4219-bd84-4268c40ccc21
Local pid:
pubs:125207
Deposit date:
2013-11-16

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