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Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth.

Abstract:

As there is evidence that in multiple sclerosis T-cell activation occurs in the central nervous system rather than outside, the inflammatory lesion may be extended through antigen presentation by cells at the edge of the plaque. In this study we present an immunocytochemical report on CNS tissue from an active case of MS, with an analysis of the distribution of CD4 and CD8 binding T cells and the expression of class I and II MHC determinants in plaques and white matter. Perivascular cuffs of ...

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Publication status:
Published

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Authors


Woodroofe, MN More by this author
Bellamy, AS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Davison, AN More by this author
Cuzner, ML More by this author
Journal:
Journal of the neurological sciences
Volume:
74
Issue:
2-3
Pages:
135-152
Publication date:
1986-07-05
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
URN:
uuid:354f3193-fe8d-4972-b7e3-571c3f9a9647
Source identifiers:
481698
Local pid:
pubs:481698

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