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The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.

Abstract:

The transport of calcium ions (Ca(2+)) to the cytosol is essential for immunoreceptor signaling, regulating lymphocyte differentiation, activation, and effector function. Increases in cytosolic-free Ca(2+) concentrations are thought to be mediated through two interconnected and complementary mechanisms: the release of endoplasmic reticulum Ca(2+) "stores" and "store-operated" Ca(2+) entry via plasma membrane channels. However, the identity of molecular components conducting Ca(2+) currents wi...

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Publication status:
Published

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Authors


Omilusik, K More by this author
Priatel, JJ More by this author
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Journal:
Immunity
Volume:
35
Issue:
3
Pages:
349-360
Publication date:
2011-09-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:3519cb4e-1d17-410c-b2b2-a3d8f800fd28
Source identifiers:
192860
Local pid:
pubs:192860

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