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ATPase site architecture and helicase mechanism of an archaeal MCM.

Abstract:

The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM complex, are members of the AAA+ (ATPase-associated with various cellular activities) family of ATPases. Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes. Here, we investigate the function of the AAA+ site in the mini-chromosome maintenance (MCM) complex of the archaeon Sulfolobus solfataricus (SsoMCM). We find that SsoMCM has an unusu...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Molecular cell
Volume:
28
Issue:
2
Pages:
304-314
Publication date:
2007-10-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:35106f8c-0b7a-4c0a-b1ef-ec8e85ea90d9
Source identifiers:
15344
Local pid:
pubs:15344

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