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Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory.

Abstract:

Gap junctions containing connexin 36 electrically couple interneurons in many brain regions and synchronize their activity. We used connexin-36 knock-out mice (Cx36(-/-)) to study the importance of electrical coupling between interneurons for spatial coding in the hippocampus and for different forms of hippocampus-dependent spatial memory. Recordings in behaving mice revealed that the spatial selectivity of hippocampal pyramidal neurons was reduced and less stable in Cx36(-/-) mice. Altered n...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
31
Issue:
17
Pages:
6542-6552
Publication date:
2011-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:350b8a26-c275-4275-a8de-5e5e4ddb86b6
Source identifiers:
135011
Local pid:
pubs:135011

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