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Journal article

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.

Abstract:
The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
Publication status:
Published

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Publisher copy:
10.1038/ng.251

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Nature genetics
Volume:
40
Issue:
12
Pages:
1402-1403
Publication date:
2008-12-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
34475
Language:
English
Keywords:
Pubs id:
pubs:34475
UUID:
uuid:34ff934e-b2be-4675-bea5-2a1cd7eb24be
Local pid:
pubs:34475
Deposit date:
2012-12-19

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