- Abstract:
- The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
- Publication status:
- Published
- Publisher copy:
- 10.1038/ng.251
-
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- Journal:
- Nature genetics
- Volume:
- 40
- Issue:
- 12
- Pages:
- 1402-1403
- Publication date:
- 2008-12-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:34ff934e-b2be-4675-bea5-2a1cd7eb24be
- Source identifiers:
-
34475
- Local pid:
- pubs:34475
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
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