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Journal article

Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice.

Abstract:

A number of experimental antibody mediated cancer therapies aim to redirect cytotoxic T cells (CTLs) of non-tumour specificity to cancer cells. It has been previously demonstrated that cancer cells targeted with recombinant HLA-class I/viral peptide complexes via antibody delivery systems can be killed by virus specific CTLs. This novel therapeutic system has been developed with a simple pre-clinical model using the recombinant anti-CD20 B9E9 scFvSA fusion protein to target HLA-A2/peptide com...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.10219

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Journal:
International journal of cancer. Journal international du cancer
Volume:
98
Issue:
4
Pages:
561-566
Publication date:
2002-04-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:34f57605-6831-4375-bf87-2f0b48eed458
Source identifiers:
102222
Local pid:
pubs:102222

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