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Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum malaria.

Abstract:

Pregnancy-associated malaria (PAM) is an important cause of maternal and neonatal suffering. It is caused by Plasmodium falciparum capable of inhabiting the placenta through expression of particular variant surface antigens (VSA) with affinity for proteoglycans such as chondroitin sulfate A. Protective immunity to PAM develops following exposure to parasites inhabiting the placenta, and primigravidae are therefore particularly susceptible to PAM. The adverse consequences of PAM in primigravid...

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Publication status:
Published

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Authors


Staalsoe, T More by this author
Shulman, CE More by this author
Dorman, EK More by this author
Kawuondo, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Infection and immunity
Volume:
72
Issue:
9
Pages:
5027-5030
Publication date:
2004-09-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:34efca88-2499-4a55-a236-59c697267329
Source identifiers:
140125
Local pid:
pubs:140125

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