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Journal article

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Abstract:

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discover that FBXL19 recruits CDK-Mediator to CpG island-associated promoters of non-transcribed developmental genes to prime these genes for activation during cell lineage commitment....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/elife.37084

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Japan Agency for Medical Research and Development More from this funder
Lister Institute of Preventive Medicine More from this funder
Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
e37084
Publication date:
2018-05-29
Acceptance date:
2018-05-26
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pubs id:
pubs:854224
URN:
uri:34c264ee-9f86-4c89-86e2-7cc47cb31cc6
UUID:
uuid:34c264ee-9f86-4c89-86e2-7cc47cb31cc6
Local pid:
pubs:854224

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