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High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya.

Abstract:

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya. SCA was associated with an increased risk of admission to hospital both with nonmalaria diseases in general (odds ratio [OR] = 4.17; 95% confidence interval [CI], 1.95-8.92; P < .001) and with inv...

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Publication status:
Published

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Authors


McAuley, CF More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Macharia, A More by this author
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Journal:
Blood
Volume:
116
Issue:
10
Pages:
1663-1668
Publication date:
2010-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:34bbb804-acd3-4b0b-8615-95cee6a6f4c8
Source identifiers:
60447
Local pid:
pubs:60447

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