- Abstract:
-
Motivation: ssRNA (single stranded) viral genomes are generally constrained in length and utilize overlapping reading frames to maximally exploit the coding potential within the genome length restrictions. This overlapping coding phenomenon leads to complex evolutionary constraints operating on the genome. In regions which code for more than one protein, silent mutations in one reading frame generally have a protein coding effect in another. To maximize coding flexibility in all reading frame...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/bioinformatics/bt/092
-
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- Journal:
- BIOINFORMATICS
- Volume:
- 22
- Issue:
- 11
- Pages:
- 1308-1316
- Publication date:
- 2006-06-01
- DOI:
- EISSN:
-
1460-2059
- ISSN:
-
1367-4803
- URN:
-
uuid:34bb7d48-0d8f-46ba-9c11-30ddd8d95a73
- Source identifiers:
-
103005
- Local pid:
- pubs:103005
- Language:
- English
- Copyright date:
- 2006
Journal article
Using hidden Markov models and observed evolution to annotate viral genomes
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