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Journal article

Using hidden Markov models and observed evolution to annotate viral genomes

Abstract:

Motivation: ssRNA (single stranded) viral genomes are generally constrained in length and utilize overlapping reading frames to maximally exploit the coding potential within the genome length restrictions. This overlapping coding phenomenon leads to complex evolutionary constraints operating on the genome. In regions which code for more than one protein, silent mutations in one reading frame generally have a protein coding effect in another. To maximize coding flexibility in all reading frame...

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Publication status:
Published

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Journal:
BIOINFORMATICS
Volume:
22
Issue:
11
Pages:
1308-1316
Publication date:
2006-06-01
DOI:
EISSN:
1460-2059
ISSN:
1367-4803
URN:
uuid:34bb7d48-0d8f-46ba-9c11-30ddd8d95a73
Source identifiers:
103005
Local pid:
pubs:103005
Language:
English

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