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Oxidative stress overrides the spindle checkpoint.

Abstract:

Aneuploidy, an abnormal chromosome set, can ensue from failure of the spindle checkpoint, the safeguard mechanism that halts anaphase onset until mitotic spindle assembly. Inefficiency of cells to maintain the normal chromosome set across cell generations has been linked to tumorigenesis and senescence. Here we show that oxidative stress overrides the spindle checkpoint mechanism. Oxidant challenge of checkpoint-arrested cells led to proteolysis of the anaphase inhibitor securin and mitotic c...

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Publisher copy:
10.4161/cc.6.5.3934

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
6
Issue:
5
Pages:
576-579
Publication date:
2007-03-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:34b198cc-3066-4bbc-ae9f-39bd0f25af5e
Source identifiers:
383502
Local pid:
pubs:383502

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