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Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity.

Abstract:

RATIONALE: A number of previous studies have reported that the Maudsley reactive (MR/Har) and non-reactive (MNRA/Har) strains of rats show behavioural and physiological differences consistent with the hypothesis that these strains differ in emotionality and could therefore be considered a model of trait anxiety in humans. OBJECTIVES: We sought to confirm this observation by determining their behaviour in various animal models of conditioned and unconditioned fear. METHODS: Both strains were e...

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Publication status:
Published

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Publisher copy:
10.1007/s002130000640

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Psychopharmacology
Volume:
154
Issue:
4
Pages:
336-342
Publication date:
2001-04-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:34a73b96-7d97-47b0-8ff5-b03617870c6e
Source identifiers:
5261
Local pid:
pubs:5261

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