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Journal article

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Abstract:

A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA. © 2013 The Authors. Published by Wiley-VCH Verlag GmbH and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/anie.201304686

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Funding agency for:
Elkins, JM
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Funding agency for:
Elkins, JM
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Funding agency for:
Elkins, JM
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Publisher:
Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim Publisher's website
Journal:
Angewandte Chemie (International ed. in English) Journal website
Volume:
52
Issue:
46
Pages:
12187-12191
Publication date:
2013-11-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:34a445e1-dfb6-4070-86da-e67d6a4d4a52
Source identifiers:
440336
Local pid:
pubs:440336

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