A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA. © 2013 The Authors. Published by Wiley-VCH Verlag GmbH and ...Expand abstract
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- Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim Publisher's website
- Angewandte Chemie (International ed. in English) Journal website
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- Gesa Schäfer et al.
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- © 2013 Gesa Schäfer et al. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
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