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An N-ethyl-N-nitrosourea (ENU) mutagenized mouse model for autosomal dominant non-syndromic kyphoscoliosis due to vertebral fusion

Abstract:

Kyphosis and scoliosis are common spinal disorders that occur as part of complex syndromes or as non-syndromic, idiopathic diseases. Familial and twin studies implicate genetic involvement, although the causative genes for idiopathic kyphoscoliosis remain to be identified. To facilitate these studies, we investigated progeny of mice treated with the chemical mutagen N-ethyl-N-nitrosourea (ENU) and assessed them for morphological and radiographic abnormalities. This identified a mouse with kyp...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/jbm4.10033

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Thomas, GP More by this author
Coulton, LA More by this author
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Publisher:
Wiley Publisher's website
Journal:
JBMR Plus Journal website
Volume:
2
Issue:
3
Pages:
154-163
Publication date:
2018-01-17
Acceptance date:
2018-01-14
DOI:
EISSN:
2473-4039
Pubs id:
pubs:825536
URN:
uri:34a26d21-be0d-47e5-803e-8c98e4524c53
UUID:
uuid:34a26d21-be0d-47e5-803e-8c98e4524c53
Local pid:
pubs:825536

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