The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.

Journal article

Cytokinesis follows separase activation and chromosome segregation. This order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylates key conserved Cdk1-substrates exemplified by the anaphase spindle-elongation protein Ase1p. However, in metazoans, MEN and Cdc14 function is not conserved. Instead, the PP2A-B55α/ENSA/Greatwall (BEG) pathway controls the human Ase1p ortholog PRC1. In this pathway, PP2A-B55 inhibition is coupled to Cdk1-cyclin B activity, wh...

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Authors: Cundell, M; Bastos, R; Zhang, T; Holder, J; Gruneberg, U

• Publication status: Published
• Journal: Molecular cell
• Volume: 52
• Issue: 3
• Pages: 393-405
• Publication date: 2013-11-01
• DOI: 10.1016/j.molcel.2013.09.005
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Signal Transduction; Chromosomes; Chromosome Segregation; Hela Cells; Protein-Serine-Threonine Kinases; Microtubule-Associated Proteins; Humans; Protein Phosphatase 2; Cytokinesis; Separase; CDC2 Protein Kinase; Mitosis; Cyclin B; Phosphoric Monoester Hydrolases