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Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI.

Abstract:

Methotrexate (MTX) is an indispensable antimetabolite for the treatment of oncological and immunological disorders in all age groups. Chronic leukoencephalopathy is a well know side effect of MTX, especially in conjunction with intrathecal administration and whole brain radio therapy. However, acute neurotoxicity with confusion, disorientation, seizures and focal deficits has also been reported. Because acute neurological symptoms in patients under chemotherapy for neoplastic disorders may ha...

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Publisher copy:
10.1007/s11060-004-2929-y

Authors


Herrlinger, U More by this author
Nägele, T More by this author
Journal:
Journal of neuro-oncology
Volume:
73
Issue:
1
Pages:
47-49
Publication date:
2005-05-05
DOI:
EISSN:
1573-7373
ISSN:
0167-594X
URN:
uuid:3498a7f6-526f-4b0f-ae96-2b20627df3f1
Source identifiers:
240903
Local pid:
pubs:240903

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