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Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice

Abstract:

Pulmonary NEB, widely distributed within the airway mucosa of mammalian lungs, are presumed hypoxia sensitive airway O2 sensors responding to changes in airway gas concentration. NEB cell hyperplasia has been reported after exposure to chronic hypoxia and in a variety of paediatric and adult lung disorders. Prolyl hydroxylases (PHD 1-3) regulate the stability of hypoxia-inducible factors (HIF's) in an O2-dependent manner and function as intrinsic oxygen sensors. To determine a possible role o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
Publisher:
Springer Netherlands Publisher's website
Journal:
Advances in Experimental Medicine and Biology Journal website
Volume:
758
Pages:
149-155
Publication date:
2012-12-07
DOI:
ISSN:
0065-2598
URN:
uuid:34923c91-fe4d-441e-9c57-03741ce843bf
Source identifiers:
368108
Local pid:
pubs:368108
ISBN:
978-94-007-4584-1

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