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Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region.

Abstract:

Interferon-gamma, encoded by IFNG, is a key immunological mediator that is believed to play both a protective and a pathological role in malaria. Here, we investigate the relationship between IFNG variation and susceptibility to malaria. We began by analysing West African and European haplotype structure and patterns of linkage disequilibrium across a 100 kb genomic region encompassing IFNG and its immediate neighbours IL22 and IL26. A large case-control study of severe malaria in a West Afri...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gene.6364214

Authors


Rockett, K More by this author
Sisay-Joof, F More by this author
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Journal:
Genes and immunity
Volume:
6
Issue:
4
Pages:
312-318
Publication date:
2005-06-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:3489ce06-cc68-450e-82d6-117386c926db
Source identifiers:
133488
Local pid:
pubs:133488

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