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5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break.

Abstract:

Ionizing radiation can induce clustered DNA damage (two or more lesions formed within one to two helical turns of DNA by passage of a single ionization track). Using oligonucleotide constructs containing clustered DNA lesions at defined positions, evidence is presented demonstrating that a persistent 5,6-dihydrothymine (DHT) lesion reduces the efficiency of rejoining, in mammalian nuclear extracts, of an opposing AP site or SSB when within 5 bp. The efficiency of repair of the SSB is reduced ...

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Publication status:
Published

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Publisher copy:
10.1667/rr1830.1

Authors


Cunniffe, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Radiation research
Volume:
172
Issue:
5
Pages:
537-549
Publication date:
2009-11-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:34805843-d587-47e7-b33f-dd9f99cc846b
Source identifiers:
130964
Local pid:
pubs:130964

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