Multiple sources of passive stress relaxation in muscle fibres.

Journal article

The forces developed during stretch of nonactivated muscle consist of velocity-sensitive (viscous/viscoelastic) and velocity-insensitive (elastic) components. At the myofibrillar level, the elastic-force component has been described in terms of the entropic-spring properties of the giant protein titin, but entropic elasticity cannot account for viscoelastic properties, such as stress relaxation. Here we examine the contribution of titin to passive stress relaxation of isolated rat-cardiac myo...

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Authors: Linke, W; Leake, M

• Journal: Physics in medicine and biology
• Volume: 49
• Issue: 16
• Pages: 3613-3627
• Publication date: 2004-08-01
• DOI: 10.1088/0031-9155/49/16/009
• EISSN: 1361-6560
• ISSN: 0031-9155
• Language: English
• Keywords: Stress, Mechanical; Protein Structure, Tertiary; Animals; Myocytes, Cardiac; Microscopy, Atomic Force; Immunoglobulins; alpha-Crystallin B Chain; Rats; Protein Kinases; Myofibrils; Myocardium; Time Factors; Actins; Protein Folding; Muscle Fibers, Skeletal; Muscle Relaxation; Monte Carlo Method; Cloning, Molecular; Muscle Contraction; Muscle Proteins; Calcium; Models, Statistical