- Abstract:
-
BACKGROUND: BNIP3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of BNIP3 in prostate cancer. METHODS: The expression of BNIP3, the androgen receptor (AR), hypoxia inducible factor (HIF)-1alpha, HIF-2alpha and the hypoxia regulated gene GLUT1 were assessed in tissue microarrays constructed from 149 radical prostatectomy specimens. Statistics compared expression of these factors between each other, con...
Expand abstract - Publication status:
- Published
- Journal:
- The Prostate
- Volume:
- 68
- Issue:
- 3
- Pages:
- 336-343
- Publication date:
- 2008-02-05
- DOI:
- EISSN:
-
1097-0045
- ISSN:
-
0270-4137
- URN:
-
uuid:3478296e-32a9-4a3a-9ff7-24d25426d28c
- Source identifiers:
-
125235
- Local pid:
- pubs:125235
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
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