Journal article icon

Journal article

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.

Abstract:

BACKGROUND: BNIP3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of BNIP3 in prostate cancer. METHODS: The expression of BNIP3, the androgen receptor (AR), hypoxia inducible factor (HIF)-1alpha, HIF-2alpha and the hypoxia regulated gene GLUT1 were assessed in tissue microarrays constructed from 149 radical prostatectomy specimens. Statistics compared expression of these factors between each other, con...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/pros.20707

Authors


Launchbury, R More by this author
Expand authors...
Journal:
The Prostate
Volume:
68
Issue:
3
Pages:
336-343
Publication date:
2008-02-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:3478296e-32a9-4a3a-9ff7-24d25426d28c
Source identifiers:
125235
Local pid:
pubs:125235

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP