Matrix metalloproteinase-2 in a murine model of infantile-type polycystic kidney disease.

Journal article

It was previously found that elevated levels of matrix metalloproteinase (MMP)-2 (gelatinase A) and -9 (gelatinase B) were synthesized and secreted into the medium by cultured kidney tubules derived from cystic C57BL/6J-cpk mice. To determine whether increased synthesis and secretion occur in vivo in this mouse model of polycystic kidney disease, kidney protein extracts, mRNA, and tissue sections were compared for expression and activity of MMP-2 and -9. Although both MMP were detected in tis...

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Authors: Rankin, C; Itoh, Y; Tian, C; Ziemer, D; Calvet, J

• Journal: Journal of the American Society of Nephrology : JASN
• Volume: 10
• Issue: 2
• Pages: 210-217
• Publication date: 1999-02-01
• EISSN: 1533-3450
• ISSN: 1046-6673
• Language: English
• Keywords: Immunohistochemistry; Mice, Inbred C57BL; Metalloendopeptidases; Kidney; Animals; Collagenases; Histocytochemistry; Disease Progression; Polycystic Kidney Diseases; Mice; Gelatinases; Animals, Newborn; Matrix Metalloproteinase 9; Matrix Metalloproteinase 2; Tissue Distribution