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Journal article

Amifostine protects mouse liver against radiation-induced autophagy blockage

Abstract:

Background/Aim: Amifostine is the only selective normal tissue cytoprotector, approved for the protection against platinum toxicities and radiotherapy-induced xerostomia. Free radical scavenger and DNA repair activities have been attributed to the drug. Materials and Methods: We investigated the effect of amifostine on autophagy, lysosomal biogenesis and lipophagy of normal mouse liver exposed to clinically relevant doses of radiation. Results: The study provides evidence that ionizing radiat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.21873/anticanres.12212

Authors


Koukourakis, MI More by this author
Giatromanolaki, A More by this author
Fylaktakidou, K More by this author
Kouroupi, M More by this author
Sivridis, E More by this author
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Publisher:
International Institute of Anticancer Research Publisher's website
Journal:
Anticancer Research Journal website
Volume:
38
Issue:
1
Pages:
227-238
Publication date:
2018
Acceptance date:
2017-11-14
DOI:
EISSN:
1791-7530
ISSN:
0250-7005
Pubs id:
pubs:815363
URN:
uri:34656385-90c6-40b4-82e6-ee8064bffe34
UUID:
uuid:34656385-90c6-40b4-82e6-ee8064bffe34
Local pid:
pubs:815363

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