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Journal article

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

Abstract:

We investigated on the mechanism responsible for the reduced ATP-sensitive K(+)(K(ATP)) channel activity recorded from skeletal muscle of K(+)-depleted rats. Patch-clamp and gene expression measurements of K(ATP) channel subunits were performed. A down-regulation of the K(ATP) channel subunits Kir6.2(-70%) and SUR2A(-46%) in skeletal muscles of K(+)-depleted rats but no changes in the expression of Kir6.1, SUR1 and SUR2B subunits were observed. A reduced K(ATP) channel currents of -69.5% in K...

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Publication status:
Published

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Publisher copy:
10.1016/j.nmd.2007.07.009

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Neuromuscular disorders : NMD
Volume:
18
Issue:
1
Pages:
74-80
Publication date:
2008-01-05
DOI:
EISSN:
1873-2364
ISSN:
0960-8966
URN:
uuid:3461ccbd-c3a1-4c03-857a-fe28fdfa57ec
Source identifiers:
114756
Local pid:
pubs:114756

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