- Abstract:
-
We investigated on the mechanism responsible for the reduced ATP-sensitive K(+)(K(ATP)) channel activity recorded from skeletal muscle of K(+)-depleted rats. Patch-clamp and gene expression measurements of K(ATP) channel subunits were performed. A down-regulation of the K(ATP) channel subunits Kir6.2(-70%) and SUR2A(-46%) in skeletal muscles of K(+)-depleted rats but no changes in the expression of Kir6.1, SUR1 and SUR2B subunits were observed. A reduced K(ATP) channel currents of -69.5% in K...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.nmd.2007.07.009
-
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- Journal:
- Neuromuscular disorders : NMD
- Volume:
- 18
- Issue:
- 1
- Pages:
- 74-80
- Publication date:
- 2008-01-05
- DOI:
- EISSN:
-
1873-2364
- ISSN:
-
0960-8966
- URN:
-
uuid:3461ccbd-c3a1-4c03-857a-fe28fdfa57ec
- Source identifiers:
-
114756
- Local pid:
- pubs:114756
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
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