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Journal article

Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.

Abstract:

Four PLS patients underwent cerebral [(11)C]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group co...

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Publication status:
Published

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Publisher copy:
10.1007/s00415-006-0482-7

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Hammers, A More by this author
Al-Chalabi, A More by this author
Andersen, PM More by this author
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Journal:
Journal of neurology
Volume:
254
Issue:
8
Pages:
1033-1036
Publication date:
2007-08-05
DOI:
EISSN:
1432-1459
ISSN:
0340-5354
URN:
uuid:34614759-c581-402e-b3bd-5f374a6df401
Source identifiers:
373939
Local pid:
pubs:373939

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