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Evidence for successive peptide binding and quality control stages during MHC class I assembly

Abstract:

Intracellular antigens are continually presented to cytotoxic T lymphocytes by major histocompatibility complex (MHC) class I molecules, which consist of a polymorphic 43 kDa heavy chain and a 12 kDa soluble subunit β2-microglobulin (β2m), and which bind an 8–10 amino-acid antigenic peptide. The assembly of this trimolecular complex takes place in the lumen of the endoplasmic reticulum (ER) [1] and almost certainly requires cofactors. Most MHC class I molecules in the ER ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0960-9822(98)70280-5

Authors


Jonathan W. Lewis More by this author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Publisher:
Current Biology Ltd.
Journal:
Current Biology Journal website
Volume:
8
Issue:
12
Pages:
717-721
Publication date:
1998-06-05
DOI:
ISSN:
0960-9822
URN:
uuid:3455d136-e5e0-46db-865c-e022b635fc8a
Local pid:
ora:8249
Language:
English
Subjects:

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