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Thesis

The role of the HSV-1 ICP22 protein in regulation of expression of host cell genes

Subtitle:
Investigation of HSV-1 ICP22inhibition of P-TEFb, and perhaps transcriptional kinases other than P-TEFb to induce the loss of Pol II activity on host cell genes
Abstract:

The eukaryotic RNA Polymerase II (Pol II) is responsible for the synthesis of all mRNA and many small regulatory RNAs. The Herpes Simplex Virus 1 (HSV-1) relies exclusively on the host Pol II to synthesise viral RNA during productive infection. A repeating structure on the carboxy terminal domain (CTD) of the Pol II largest subunit consisting of consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, has to be phosphorylated to drive Pol II-mediated transcription. The ICP22 protein of HSV-1...

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Nur Firdaus Isa More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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