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Inward rectification in KATP channels: a pH switch in the pore.

Abstract:

Inward-rectifier potassium channels (Kir channels) stabilize the resting membrane potential and set a threshold for excitation in many types of cell. This function arises from voltage-dependent rectification of these channels due to blockage by intracellular polyamines. In all Kir channels studied to date, the voltage-dependence of rectification is either strong or weak. Here we show that in cardiac as well as in cloned KATP channels (Kir6.2 + sulfonylurea receptor) polyamine-mediated rectifi...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/18.4.847

Authors


Baukrowitz, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Schulte, U More by this author
Benndorf, K More by this author
Ruppersberg, JP More by this author
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Journal:
The EMBO journal
Volume:
18
Issue:
4
Pages:
847-853
Publication date:
1999-02-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:34470e7a-fab7-413e-956c-1ef21cb43268
Source identifiers:
11935
Local pid:
pubs:11935

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