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Journal article

Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.

Abstract:

PURPOSE: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents. We sought to identify critical signaling pathways that contribute to their survival and proliferation, and which may provide potential targets for rational therapeutic interventions. EXPERIMENTAL DESIGN: Activation of receptor tyrosine kinases (RTK) was surveyed using phospho-RTK arrays. S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. siRNA or small-mol...

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Publication status:
Published

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Authors


van Oosterwijk, JG More by this author
Sicinska, E More by this author
Remillard, SP More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
19
Issue:
14
Pages:
3796-3807
Publication date:
2013-07-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:344077bb-7e84-4f8f-a4a2-a013347ee8bb
Source identifiers:
401867
Local pid:
pubs:401867

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