- There is abundant evidence that most non-exposed donors have cells able to respond to malaria antigens. These cells have the properties of memory T cells and probably arise as a result of cross-reactive priming by other microbial antigens. The existence of a high frequency of cross-reactive primed cells would be predicted to bias the response to malaria antigens, both in terms of specificity and the type of effector cells generated. It is possible that this bias may interfere with the development of effective anti-malaria responses.
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