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Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.

Abstract:

The identification of biologically active compounds from high-throughput screening (HTS) can involve considerable postscreening analysis to verify the nature of the sample activity. In this study we evaluated the performance of micro-parallel liquid chromatography (microPLC) as a separation-based enzyme assay platform for follow-up of compound activities found in quantitative HTS of two different targets, a hydrolase and an oxidoreductase. In an effort to couple secondary analysis to primary ...

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Publication status:
Published

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Publisher copy:
10.1089/adt.2007.097

Authors


Simeonov, A More by this author
Shafqat, N More by this author
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Journal:
Assay and drug development technologies
Volume:
5
Issue:
6
Pages:
815-824
Publication date:
2007-12-05
DOI:
EISSN:
1557-8127
ISSN:
1540-658X
URN:
uuid:343a1d55-c281-43fa-a787-7d833cb5867f
Source identifiers:
108688
Local pid:
pubs:108688

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