Journal article
Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha‐synuclein levels in Lewy body disease
- Abstract:
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Aims: Endoplasmic reticulum stress followed by the unfolded protein response is one of the cellular mechanisms contributing to the progression of α‐synuclein pathology in Parkinson's disease and other Lewy body diseases. We aimed to investigate the activation of endoplasmic reticulum stress and its correlation with α‐synuclein pathology in human post‐mortem brain tissue. Methods: We analysed brain tissue from 45 subjects—14 symptomatic patients with Lewy body disease, 19 subjects with inciden...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 10.8MB, Terms of use)
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- Publisher copy:
- 10.1111/nan.12999
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Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Neuropathology and Applied Neurobiology More from this journal
- Volume:
- 50
- Issue:
- 4
- Article number:
- e12999
- Publication date:
- 2024-07-22
- Acceptance date:
- 2024-07-01
- DOI:
- EISSN:
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1365-2990
- ISSN:
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1365-2990 and 0305-1846
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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2018581
- Local pid:
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pubs:2018581
- Source identifiers:
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2126619
- Deposit date:
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2024-07-22
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