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Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Abstract:

Hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR) are members of the bHLH-PAS family of transcription factors that underpin cellular responses to oxygen and to endogenous and exogenous ligands, respectively, and have central roles in the pathogenesis of renal cancer. Composed of heterodimers, they share a common HIF-1β/ARNT subunit and similar DNA-binding motifs, raising the possibility of crosstalk between the two transcriptional pathways. Here, we identify both general and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.26508/lsa.202201756

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
NDM Research Building
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
NDM Research Building
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
NDM Research Building
Role:
Author
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Name:
Cancer Research UK
Grant:
16016
More from this funder
Name:
National Institute for Health Research
Grant:
RP-2015-06-004
Publisher:
Life Science Alliance LLC
Journal:
Life Science Alliance More from this journal
Volume:
6
Issue:
4
Article number:
e202201756
Publication date:
2023-02-01
Acceptance date:
2023-01-12
DOI:
EISSN:
2575-1077
Language:
English
Keywords:
Pubs id:
1322024
Local pid:
pubs:1322024
Deposit date:
2023-01-13

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